Melanocortin
Melanotan II 10mg
Buy Melanotan II 10mg in Australia — >99.4% HPLC tested with batch-specific COA. Same-day Australian dispatch.
Melanocortin receptor agonist research compound. Cyclic lactam analogue of alpha-MSH investigated in MC1R/MC4R receptor binding studies.
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Melanotan II 10mg
Estimated launch price: $59 AUD
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Melanotan II Overview
Melanotan II is a synthetic cyclic lactam analogue of α-melanocyte-stimulating hormone (α-MSH). The cyclic structure locks the peptide into a bioactive conformation and confers resistance to enzymatic degradation. It has been investigated extensively as a research tool for the melanocortin receptor family (MC1R, MC3R, MC4R, MC5R).
History
Developed at the University of Arizona in the late 1980s as part of research into stable α-MSH analogues, Melanotan II became a foundational tool compound in melanocortin receptor pharmacology. It established the value of cyclic constraint as a structural strategy for peptide research design.
Melanotan II Structure
Research Findings
Melanotan II has been studied across the melanocortin receptor family with reports of varying receptor affinity and selectivity profiles. The compound is widely used as a comparator in receptor binding assays, structure-activity relationship studies, and melanocortin pharmacology research.
Key Areas of Research:
- •Melanocortin receptors: MC1R / MC3R / MC4R / MC5R binding profiles
- •Structure-activity: Cyclic lactam constraint and bioactive conformation
- •Receptor pharmacology: Comparator in receptor binding assays
References
References are provided for research context. Pillar Research does not endorse or interpret published findings as therapeutic claims.
Melanotan II 10mg — research questions
Common questions for Australian researchers about Melanotan II 10mg.
What is Melanotan II?
Melanotan II is a cyclic lactam analogue of α-melanocyte-stimulating hormone (α-MSH). It is supplied as an investigational research compound for in vitro laboratory research under the RUO framework.
What melanocortin receptors does Melanotan II target?
Melanotan II is investigated across the melanocortin receptor family: MC1R, MC3R, MC4R, and MC5R. The cyclic structure provides receptor selectivity profiles that linear α-MSH analogues do not.
Why is Melanotan II cyclic?
The cyclic lactam structure locks Melanotan II into a bioactive conformation and confers resistance to enzymatic degradation. Linear α-MSH analogues are rapidly cleaved and show different receptor binding profiles.
Is Melanotan II legal in Australia?
Melanotan II is classified as Schedule 4 (prescription-only) under the Australian Poisons Standard. It can be lawfully supplied for in vitro research purposes under the Research Use Only (RUO) framework. It is not listed on the Australian Register of Therapeutic Goods (ARTG) and is not a therapeutic good under the Therapeutic Goods Act 1989 (Cth).
How is Melanotan II verified by Pillar Research?
Every batch is independently HPLC and mass spectrometry verified by a third-party Australian laboratory. The batch-specific Certificate of Analysis is downloadable from this page.
How should Melanotan II be stored?
Store lyophilised vials at 2–8 °C, protected from light and moisture, in the original sealed vial. After reconstitution, store at 2–8 °C for short-term use or −20 °C for longer storage. Avoid repeated freeze–thaw cycles.